Integration of spatial epidemiology and pharmacoepidemiology for the practical use of the adverse drug event report database with related applications

2016 Fiscal Year Final Research Report

• Project/Area Number: 26540012
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Nagoya University
• Principal Investigator: Takahashi Kunihiko 名古屋大学, 医学系研究科, 准教授 (50323259)
• Research Collaborator: SHIMADZU Hideyasu 英国Laughborough大学, Department of Mathematical Sciences, 講師
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 空間疫学 / 薬剤疫学 / 副作用 / 自発報告 / 集積性

Outline of Final Research Achievements

We revealed similarities and differences between two publicly available database of spontaneous adverse event reports in drug uses - the Japanese Adverse Drug Event Report database and the US Food and Drug Administration Adverse Event Reporting System - and how they affect signal detection. Next, we applied a cluster detection test based on a scan statistic to a huge database of daily ambulance records of out-of-hospital cardiac arrest cases in Japan, and we could find the increased the daily incidence around every New Year’s Day. And, we performed some practical studies using databases effectively in pharmacoepidemiology, from the statistical viewpoints in spatial epidemiology and related fields.

Free Research Field

生物統計学