Biotechnological application of memory-related molecules in the brain

2017 Fiscal Year Final Research Report

• Project/Area Number: 26540154
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: Kyoto University
• Principal Investigator: Urakubo Hideotshi 京都大学, 情報学研究科, 特定研究員 (40512140)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 生体分子メモリ / シミュレーション / 再構成系 / CaMKII

Outline of Final Research Achievements

Three approaches were utilized to examine the feasibility of biotechnological application of CaMKII memory function: biochemical experiments, cellar and molecular biological experiments, and computer simulation. I developed the insect cell expression system of CaMKII-FRET, and also developed the optical observation/simulation system of target molecules in HeLa cells. The CaMKII memory system is also applicable. Also, I computationally simulated the reaction-diffusion system of the memory-related molecules in morphologically realistic dendrites and spines, to examine localization of those molecules.

Free Research Field

計算論的神経科学