2017 Fiscal Year Final Research Report
Biotechnological application of memory-related molecules in the brain
Project/Area Number |
26540154
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Life / Health / Medical informatics
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Keywords | 生体分子メモリ / シミュレーション / 再構成系 / CaMKII |
Outline of Final Research Achievements |
Three approaches were utilized to examine the feasibility of biotechnological application of CaMKII memory function: biochemical experiments, cellar and molecular biological experiments, and computer simulation. I developed the insect cell expression system of CaMKII-FRET, and also developed the optical observation/simulation system of target molecules in HeLa cells. The CaMKII memory system is also applicable. Also, I computationally simulated the reaction-diffusion system of the memory-related molecules in morphologically realistic dendrites and spines, to examine localization of those molecules.
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Free Research Field |
計算論的神経科学
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