Influences on structure and metabolism of the myocardium in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure

2015 Fiscal Year Final Research Report

• Project/Area Number: 26550039
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Osaka University
• Principal Investigator: Nakajima Hiroo 大阪大学, 医学(系)研究科(研究院), 助教 (20237275)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Takashi 大阪大学, ラジオアイソトープ総合センター, 教授 (90323336)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 福島原発事故 / セシウム１３７ / 内部被ばく影響 / 心筋 / チェルノブイリ原発事故 / 酸化ストレス / 透過電顕解析

Outline of Final Research Achievements

To investigate the structural and metabolic effects on the myocardium in descendant mice after the every generational low dose-rate internal 137Cs radiation exposure, every generations of mice were maintained in the radioisotope facility with free access to drinking water containing 137CsCl (100 Bq/ml). Mice(12 months of age) of the seventeenth generation were assessed metabolic analysis in heart, and the structure abnormality of the myocardium with the electron microscope, and were compared the influence between the offspring exposed to continuous low-dose radiation and control mice of the same generation that started from a littermate mouse.
Tendency to swelling of myocardium mitochondria and suppression of the glutathione level (p=0.033) and glycolytic pathway (nonsignificant) were observed in 137Cs drinking mice.

Free Research Field

放射線基礎医学