Analysis of metabolite and food habit in preventing recurrence for liver cancer by metabolomics

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560056
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: OKUMURA Hisami 徳島大学, 大学院医歯薬学研究部, 講師 (30322259)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 食生活 / 肝疾患 / メタボロミクス

Outline of Final Research Achievements

Metabolome analysis can make metabolite and metabolic pathway understand clearly. Perioperative nutritional management is an important for early recovery after surgery. Patients with hepatocellular carcinoma were recruited in this study. Serum and spot urine were collected before and post operative days of hepatectomy. Metabolites in serum and urine were analysed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). At POD3, serum BCAA levels did not change and AAA significantly increased, so Fischer ratio significantly decreased after liver resection.
Metabolome analyses to assess both serum and urine were useful for evaluation of metabolite accurately.

Free Research Field

臨床栄養学