2016 Fiscal Year Final Research Report
Creation of a new strategy for prevention of metabolic syndrome by colonic hydrogen
| Project/Area Number |
26560059
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Shizuoka University (2015-2016)
Nayoro City University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 水素 / 大腸発酵 / メタボリックシンドローム / 難消化性糖質 |
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| Outline of Final Research Achievements |
We examined whether the reducing power of hydrogen molecules (H2) generated by colonic fermentation could suppress inflammation in diet-induced obese rats. Additionally, we sought to determine the minimum amount of fermentation substrate needed to maintain high colonic H2 production for 24 h. We found that a high production of colonic H2 over 24h, derived from the delivery to the large intestine of more non-digestible saccharides than could be used, increased the concentration of H2 in the adipose tissue and suppressed the secretion of IL-6, which is a proinflammatory cytokine. In short, a high H2 production from the large intestine over a 24 h period was achievable when sufficient amounts of non-digestible saccharides were delivered to the large intestine as a fermentation substrate, with the resultant high production of H2 leading to inhibited metabolic syndrome via the alleviation of inflammation.
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| Free Research Field |
栄養化学
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