2016 Fiscal Year Final Research Report
The study on the bio-marker for fatigue, and the development of the functional food
| Project/Area Number |
26560070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 食用きのこ / 炎症抑制作用 / 樹状細胞 / マクロファージ / 免疫調節作用 / βグルカン |
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| Outline of Final Research Achievements |
It has been shown that a fatigue could be caused by the inflammatory response of immune cells such as dendritic cells, macrophages and monocytes. In this study, the author has shown that both pro- and anti-inflammatory cytokines could become good bio-markers to diagnose fatigue. Moreover, some mushroom showed anti-inflammatory effect on the immune cells. And, the glucan from Pleurotus cornucopiae mushroom could suppress a differentiation of monocyte into inflamed macrophage despite the finding that the glucan induced to inflame matured dendritic cells, macrophages and monocytes. Therefore, this study has considered that some mushrooms can inhibit inflammation of immune cells, and prevent the fatigue.
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| Free Research Field |
食品科学
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