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2015 Fiscal Year Final Research Report

Studies on disposition of vitamin K and development of novel method for nutritional assessment of vitamin K using urine metabolite

Research Project

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Project/Area Number 26560072
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKobe Pharmaceutical University

Principal Investigator

Kamao Maya  神戸薬科大学, 薬学部, 助手 (40299087)

Project Period (FY) 2014-04-01 – 2016-03-31
KeywordsビタミンK / phylloquinone / menaquinone-4 / menadione / 抱合体 / 尿中排泄
Outline of Final Research Achievements

Determination method for vitamin K3 (menadione, MD) by LC-MS/MS was developed. MD is thought to be an intermediate in the conversion from vitamin K1 (phylloquinone, PK) to vitamin K2 (menaquinone-4, MK-4). Using this method, we demonstrated that MD was generated from PK or MK-4 in liver, kidney, intestine and bone derived cells. Thus, side-chain cleaving toward vitamin K is assumed to be universal reaction in various tissues. Our results raise the possibility that MD might exist as a glucuronide in human urine mainly and a glutathione or N-acetylcysteine conjugate in mouse plasma.

Free Research Field

衛生薬学、栄養化学

URL: 

Published: 2017-05-10  

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