Relationship between the gastric mucosa condition and shrimp allergy risk developing or sensitization.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560077
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: National Fisheries University
• Principal Investigator: Usui Masakatsu 独立行政法人水産大学校, その他部局等, 准教授 (50399656)
• Co-Investigator(Renkei-kenkyūsha): Azakami Hiroyuki 山口大学, 農学部, 教授 (40263850)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: エビアレルギー / トロポミオシン / 胃粘膜 / 急性胃炎 / 重篤化 / 感作

Outline of Final Research Achievements

To investigate about a relation between deterioration of the gastric mucosa environment and allergy to shrimps, we prepared the shrimp allergy mouse model by 4 times of intra-gastric administration with cholera toxin. After gastritis induction by 25% ethanol administration, these model mice were challenged by receiving one intra-gastric dose of shrimp allergens. Production levels of shrimp allergen-specific IgE were higher than healthy gastric control mice group in gastritis mice group. In addition, the production levels of shrimp allergen-specific IgE in mice sensitized with gastritis induction showed the increased tendency compared to healthy mice.

Free Research Field

複合領域　食生活学