2016 Fiscal Year Final Research Report
Clarification of mechanical interaction between erythrocytes and endothelial cells in an inclined centrifugal force field
| Project/Area Number |
26560198
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
INOUE KOSUKE 東北大学, 流体科学研究所, 技術専門職員
MIYAUCHI SUGURU 東北大学, 流体科学研究所, 助教
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 細胞バイオメカニクス / 傾斜遠心顕微鏡 |
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| Outline of Final Research Achievements |
Elucidation of the mechanical interaction between an erythrocyte and an endothelial cell is an important issue relating to mechanisms of cardiovascular diseases. The objective of this study was to clarify the mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate. Three-dimensional numerical simulation was performed with contact force models between an erythrocyte and glycocalyx on the surface of endothelial cells and two-dimensional analysis was conducted using a lubrication theory for compressible porous media and a simple erythrocyte model. In the 3D simulation, two contact force models were adopted in which shear stresses acting on the bottom surface of an erythrocyte varied proportional or inversely proportional to the distance to the base plate. As a result, the experimental frictional characteristics for an endothelia-cultured plate were properly reproduced by the inverse proportion model.
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| Free Research Field |
流体工学
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