3D microstructure of actin stress fibers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560208
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University (2016); Nagoya Institute of Technology (2014-2015)
• Principal Investigator: Deguchi Shinji 大阪大学, 基礎工学研究科, 教授 (30379713)
• Co-Investigator(Renkei-kenkyūsha): MATSUI Tsubasa 大阪大学, 大学院基礎工学研究科, 講師 (50638707)
• Research Collaborator: IMAMURA Michihiro 国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長 (80221787)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ストレスファイバー / 焦点接着斑 / 非筋α-アクチニン

Outline of Final Research Achievements

Stress fibers (SFs) are filamentous protein complexes present within nonmuscle cells. SFs have been implicated in various cellular functions including control of pro-inflammatory signaling, but as their 3D microstructure remains unclear, the molecular/physical mechanisms underlying the diverse functions remain to be elucidated. Here we isolated functional SFs to reveal a specific microstructure associated with nonmuscle alpha-actinin at the boundary between the individual SFs and focal adhesions that are located at the termini of the SFs.

Free Research Field

細胞バイオメカニクス