Heart Tissue Engineering: Integration of microfabrication technology and THz wave

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560209
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyoto University
• Principal Investigator: Kamei Ken-ichiro 京都大学, 物質－細胞統合システム拠点, 特定拠点准教授 (00588262)
• Co-Investigator(Renkei-kenkyūsha): 廣理 英基 京都大学, 物質-細胞統合システム拠点, 特定拠点准教授 (00512469)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 幹細胞 / マイクロ流体デバイス / THz / 組織工学 / 心筋細胞

Outline of Final Research Achievements

We aimed to develop a new platform to obtain functional and mature cardiomyocytes derived from human embryonic stem (ES) and induced pluripotent stem (iPS) cells by utilizing a microfluidic device in combination with THz wave. Specifically, A. to develop a microfluidic device allowing three-dimensional cell culture for cardiomyocytes, B. to combine the experimental setups of both THz microscope and microfluidic devices, C. to make mature cardiomyocytes by irradiating THz wave. Our devices would be very beneficial for regenerative medicine as well as drug screening for heart diseases.

Free Research Field

幹細胞工学