Development of a bioartificial liver using genetically modified hepatoma cells with inducible high liver functions

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560216
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kyushu University
• Principal Investigator: Kamihira Masamichi 九州大学, 工学(系)研究科(研究院), 教授 (40202022)
• Co-Investigator(Renkei-kenkyūsha): IJIMA HIROYUKI 九州大学, 大学院工学研究院, 教授 (10274515) ; MIZUMOTO HIROSHI 九州大学, 大学院工学研究院, 准教授 (90346817)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 生物・生体工学 / 細胞・組織 / バイオリアクター / 人工臓器工学

Outline of Final Research Achievements

We have created genetically modified hepatoma cells (Super-hepatoma) with high liver functions, comparable to those of primary hepatocytes, by inducible overexpression of eight liver-specific transcription factors. To construct a bioartificial liver system using the Super-hepatoma, the cells were modified with a novel induction system for functionalization and the cell immobilization conditions were examined for fabrication of a bioartificial liver module.

Free Research Field

生物工学