Development of a neurotransmitter-sensor using molecularly imprinted polymer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560223
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Shibaura Institute of Technology
• Principal Investigator: Yoshimi Yasuo 芝浦工業大学, 工学部, 教授 (30267421)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 分子インプリント高分子 / 分子認識 / セロトニン / バイオセンサ / グラフト重合 / 電子移動 / 神経 / 学習

Outline of Final Research Achievements

We attempted a neurotransmitter-sensor using molecularly imprinted polymer (MIP) . Poly(Methacrylic acid-co-ethyleneglycoldimethacrylate-co-vynylferrocene) was grafted onto indium-tin oxide electrodes imprinted with serotonin. The differential current between the grafted electrodes imprinted or non-imprinted with serotonin was sensitive to serotonin with selectivity. The result indicated that pair of the imprinted and the non-imprinted electrodes are useful as a serotonin sensor. We also discovered S-cluster in Apllysia buccal ganglion response to taste stimulation with indicating learning. Then those results indicates that pair of the grafted electrodes implanted in the S-cluster of Aplysia would be helpful for development of a new model of brain-machine interface by detection of serotonin release regulated by learning of the animal for control of machine.

Free Research Field

バイオエレクトロニクス、医用化学工学