Development of biofuel cell-based iontophoresis DDS for intraocular drug delivery

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560232
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: Nagai Nobuhiro 東北大学, 医学(系)研究科(研究院), 助教 (30400039)
• Co-Investigator(Kenkyū-buntansha): Kaji Hirokazu 東北大学, 大学院工学研究科, 准教授 (70431525)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ドラッグデリバリー / 網膜 / イオントフォレシス

Outline of Final Research Achievements

The mold for device preparation was fabricated using CAD/CAM-based microprocessing and polydimethylsiloxane. An in vitro chamber model using rabbits sclera showed that constant electric stimulation (0.1mA) facilitate drug permeation through the sclera. Measurement of drug concentration in the plasma after device implantation on the rabbit sclera showed that there was a correlation between drug release profile of the device and drug concentration in the plasma. In the future work, electric generation in the device should be improved and the effect of the iontophoresis using the device on intraocular drug delivery would be evaluated by measuring the drug concentration in the plasma.

Free Research Field

ドラッグデリバリー