Preparation of micro-size in-cell magnetic stirrer for controlling cell behaviors

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560237
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIHARA KAZUHIKO 東京大学, 工学(系)研究科(研究院), 教授 (90193341)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: バイオマテリアル / 磁性粒子 / 高分子合成 / ナノ粒子 / 細胞・組織 / 生体親和性

Outline of Final Research Achievements

To achieve active control of cellular circumstances, we consider the control of chemical reactions in cells by using an intracellular magnetic stirring device　is consisted of the Fe3O4-encapsulated anisotropic polymer nanoparticles covered with phospholipid polymers. This is a new intracellular device, which rotates in cells and enables the direct analysis of intracellular circumstances and control of cell functions. The Fe3O4-encapsulated polystyrene (PSt) spherical nanoparticles were prepared by the soap-free polymerization. The physical anisotropy was given to the nanoparticles by stretching the nanoparticles-embedded poly(vinyl alcohol) (PVA) film at 160°C. After the physical stretch, the major axis was enlarged to about 330 nm and the minor axis was shortened to about 130 nm. The nanoparticle could rotate by alternative magnetic fields. That is world most small magnetic stirrer has been obtained.

Free Research Field

バイオマテリアル工学