Preparation of cellular roll for regenerative artificial blood vessels using biodegradable shape-memory polymers

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560248
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kansai University
• Principal Investigator: Ohya Yuichi 関西大学, 化学生命工学部, 教授 (10213886)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 形状記憶ポリマー / 人工血管 / 生分解性高分子 / 階層構造 / 再生医療

Outline of Final Research Achievements

In order to regenerate the living tissue, reconstruction of 3-dimensional hierarchical structures of the tissue must be important. In this study, we tried to prepare a biodegradable multi-layered cellular roll having 3-dimensional hierarchical structure consisting of different kind cells using biodegradable shape memory polymers as scaffolds for regenerative small diameter blood vessels. Then, we succeeded to prepare biodegradable polymer sheet which shows shape-recovery into roll shape. We succeeded immobilization of cell-recognition peptide on the surface of the polymer sheet.

Free Research Field

機能性高分子化学