Development of theranostics for cancer with tumor targeted bubbles and ultrasound

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560264
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Teikyo University
• Principal Investigator: Suzuki Ryo 帝京大学, 薬学部, 准教授 (90384784)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 超音波 / がん / 診断 / 治療

Outline of Final Research Achievements

In this study, we succeeded to develop novel bubbles with long half-life as ultrasound imaging agent. In addition, we modified the targeting peptide (cyclic RGD) on the bubbles. These bubbles could effectively bind to human umblical endothelial cells (HUVEC) as a model of neovascular endothelial cells in tumor tissue. From these results, it is expected that the developed bubbles would be applied for ultrasound imaging agents and therapeutic agents for cancer.

Free Research Field

薬物送達学