New model animal with fibromyalgia: peripheral mechanism and effect of exercise for that.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560275
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagasaki University
• Principal Investigator: NAKANO Jiro 長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20380834)
• Research Collaborator: OGA Satoshi
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 線維筋痛症 / 痛み / NGF / 不動 / 中枢性感作

Outline of Final Research Achievements

We examined the mechanical sensitivity, expression of nerve growth factor (NGF) and distribution of peripheral nerve fiber in skeletal muscle and central sensitization in spinal cord, after cast immobilization of rat limb. This examination was based on our hypothesis that immobilization of limb induces a muscular pain similar to fibromyalgia. At the result, mechanical hypersensitivity and increases in NGF and C nerve fibers was shown in medial gastrocnemius muscle after immobilization of ankle joint by cast. These changes lead to the increase of CGRP in dorsal horn of spinal cord and phenotype switch in DRG neuron which lead to central sensitivity. We suggested that the immobilization-induced pain could be used as a model of fibromyalgia.

Free Research Field

リハビリテーション学