The model of myogenic satellite cells fusion to myoibers

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560288
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagoya Gakuin University
• Principal Investigator: HIRANO Takayuki 名古屋学院大学, リハビリテーション学部, 教授 (10440661)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 筋衛星細胞 / 融合 / 筋収縮 / 理学療法学

Outline of Final Research Achievements

The exercise training cause facilitating recovery of atrophied muscles and increases the number of myonuclei above normal levels. These increases myonuclei numbers may through fusion of myogenic satellite cells with myofibers, but it is unclear. Therefore, we developed an in vitro model that induces muscle contraction by electrical stimulation to differentiated myotube cells with myogenic satellite cells, and investigated the fusion response of myogenic satellite cells to existing myofibers. As a result, we observed that myogenic satellite cells fusing to existing myotube cells with muscle contraction inducing by the electrical stimulation. This model could contribute to further investigations of mechanisms of fusion response of myogenic satellite cells to existing myofibers.

Free Research Field

理学療法学