Vitamin D which is a therapeutic drug of osteoporosis may have antidepressant activity by single administration.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560293
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kibi International University
• Principal Investigator: Kawaura Akihiko 吉備国際大学, 保健医療福祉学部, 教授 (00177643)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Yoshihisa 岡山大学, 医歯(薬)学総合研究科, 准教授 (40423339) ; AKIYAMA Jyunichi 吉備国際大学, 保健医療福祉学部, 准教授 (00309600) ; MIZUTANI Kasatoshi 吉備国際大学, 保健医療福祉学部, 教授 (30108170)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ビタミンD / 強制水泳試験 / オープンフィールド試験

Outline of Final Research Achievements

We examined the effect of 1α-hydroxyvitamin D3[1α(OH)D3] on forced swimming test in mice. The animals were given intragastric administration of 0.5, 1.0, 2,0 μg/kg of 1α(OH)D3 in MCT through a feeding tube. We gave 1α(OH)D3 orally 24, 3 and 1 hours before a forced swimming test. The total time (seconds) of immobility during this session was recorded and scored for 6 min simultaneously. Intragastric administration of 1 α (OH) D3 of 1.0 μg/kg reduced immobility time in the forced swimming test. We examined a change of the spontaneous momentum in an open field test to prove this reasoning that 1α(OH)D3 is different from analeptica in effects pattern. 1α(OH)D3 at all concentration (0.5, 1.0, 2.0 μg/kg ) had no effect on the locomotor study compared with control. These results suggest that 1α(OH)D3 may have antidepressant-like activity.

Free Research Field

内科学、病理学