A study to develop a new method of double mechanical stress, to examine the use of that method, and to ascertain the mechanism of action of myokines induced by that stress

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560314
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: Yamada Kouji 藤田保健衛生大学, 保健学研究科, 教授 (60278306)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨折予防 / マイオカイン / 関節炎

Outline of Final Research Achievements

Fractures due to falls and decreased bone density greatly affect the activities of daily living. In addition, arthritis is a condition that develops with aging, and this condition must be actively prevented and treated. The current study used a new method to apply 2 forms of mechanical stress to a mouse model of decreased bone density and it examined the relief of symptoms due to that stress. Results revealed that bone density actively decreased and bone metabolism actively occurred after menopause. Sufficient rest following mechanical stress presumably led to relief of symptoms of decreased bone density. An experiment involving a mouse model of arthritis also indicated that the level of expression of antiinflammatory myokines by skeletal muscle following mechanical stress increased while the level of expression of inflammatory myokines was limited. This presumably delayed the development and progression of arthritis.

Free Research Field

生理学