Non-invasive assessment of skeletal muscle membrane in human

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560354
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition (2015); National Institute of Health and Nutrition (2014)
• Principal Investigator: Yamada Yosuke 国立研究開発法人医薬基盤・健康・栄養研究所, 基礎栄養研究部, 研究員 (60550118)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yuya 京都学園大学, 研究・連携支援センター, 研究員 (70644376)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: サルコペニア / 老化 / 骨格筋

Outline of Final Research Achievements

Skeletal muscles contain a large volume of water that is classified into intracellular (ICW) and extracellular (ECW) water fractions. Segmental bioelectrical impedance spectroscopy (S-BIS) is a unique tool used to assess the segmental ratio of ECW/ICW in the limbs. We evaluated 405 community-living people. ECW and ICW in the upper legs were assessed by S-BIS. Isometric knee extension strength (KES), gait speed, and skeletal muscle mass (SM) were measured. Thigh ECW/ICW was negatively correlated with KES and gait speed (r = &#8722;0.617 and &#8722;0.431, respectively, p < 0.001) and increased with age (p < 0.001). Thigh ECW/ICW was a significant predictor of KES and gait speed independent of age, sex, BMI, and SM. Relative expansion of ECW against ICW in the thigh muscles is a factor in decreased muscle quality and a biomarker of muscle aging.

Free Research Field

運動生理学