Exploration of the visceral organs in response to the sensory afferent signals from skeletal muscles

2016 Fiscal Year Final Research Report

• Project/Area Number: 26560368
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Shigakkan University (2015-2016); University of Miyazaki (2014)
• Principal Investigator: Toshinai Koji 至学館大学, 健康科学部, 教授 (80381101)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 感覚神経級進路 / 骨格筋 / 肝臓 / 脳 / エネルギー代謝 / ATP / 糖新生

Outline of Final Research Achievements

The skeletal muscle has to keep demanding energy to maintain muscle contraction during exercise. The increasing metabolic demands of the working muscle cannot maintain without glucose supply from the liver or free fatty acids from the adipose tissue. However, It is uncertain how the information of metabolic demands of working muscle was transferred to the other visceral organs. This study suggested that the information of metabolic demands of working muscle, at least in part, is transmitted to the brain through the sensory afferent nerve. In addition, The information may induce the increase of a part of glucogenesis pathway in the liver, as a result of conversion to the activation of vagal efferent system in the brain.

Free Research Field

神経内分泌