Effects of creatine-analogue treatment on the energy metabolism in skeletal muscles

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560373
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Doshisha University
• Principal Investigator: Ohira Yoshinobu 同志社大学, スポーツ健康科学部, 教授 (50185378)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ラット骨格筋 / クレアチン枯渇 / 炭水化物代謝 / 脂質代謝

Outline of Final Research Achievements

Effects of creatine levels on the contractile and metabolic properties in skeletal muscles were studied in rats. As the results, shift toward slow-twich type was induced by beta-GPA feeding even in soleus, although such trend was prominent in extensor digitorum longus. Further, inhibition of carbohydrate metabolism and simulation of lipid utilization were induced. It was indicated that oxydative capacity of skeletal muscles was increased following chronic depetion of creatine, although daily muscle activities were less, on the contrary. These observations gave important suggestions not only for basic science, but also for the exercise training areas. However, beneficial effects by treatment using creatine were not observed.

Free Research Field

神経・筋生理学