2015 Fiscal Year Final Research Report
Is hibernation-specific protein mimetic human CTRP3 a biosensor for homeostatic balance?
| Project/Area Number |
26560389
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | CTRP3 / 生活習慣病 / バイオセンサー / NAFLD / 過体重 / 脂質異常 / 高血圧 / インスリン抵抗性 |
|---|
| Outline of Final Research Achievements |
The aim of the present study was to investigate the significance of serum C1q/TNF-related protein-3 (CTRP3) in the context of lifestyle-related diseases among non-obese young adults. We investigated 261 non-obese university freshmen (160 men and 101 women). Serum CTRP3 level was negatively correlated with BMI and systolic and diastolic blood pressures. It also negatively correlated with triglyceride, LDL-cholesterol, and HOMA-IR. In contrast, it positively correlated with HDL-cholesterol. CTRP3 level in non-alcoholic fatty liver disease (NAFLD) group was significantly higher than that in non-NAFLD group. Since serum CTRP3 level decreases in the presence of hypertension, dyslipidemia, overweight, and NAFLD, it is considered to be a biosensor to reflect the risk of lifestyle-related diseases.
|
| Free Research Field |
消化器内科学
|
