Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance development

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560397
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Kyoto University
• Principal Investigator: Nomura Wataru 京都大学, (連合)農学研究科(研究院), 助教 (60724292)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: メチルグリオキサール / インスリンシグナル / インスリン抵抗性 / IRS-1 / mTORC1

Outline of Final Research Achievements

It is pointed out that the methylglyoxal, a metabolite derived from glycolysis, is involved in diabetes, although the correlation between pathogenic mechanism of diabetes and methylglyoxal is unclear. The phosphorylation at Ser/Thr residues of IRS-1 (insulin receptor substrate) is one of the causes of insulin resistance. In this study, I found that the phosphorylation of IRS-1 is enhanced following treatment with methylglyoxal in adipocytes, and the pretreatment with methylglyoxal attenuates the activation of insulin signaling pathway.

Free Research Field

応用分子細胞生物学