Why are overweight children liable to induce allergies? -Relationship between high-carbohydrate diets and adipose tissues-

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560408
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: National Defense Medical College
• Principal Investigator: HATTORI Hidemi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター, 助教 (80508549)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脂肪細胞 / 脂肪組織由来間質細胞 / グルコース / 線維芽細胞増殖因子 / エオタキシン / サイトカイン / アレルギー

Outline of Final Research Achievements

Excessive carbohydrate intake not only leads to store to adipose tissues as energy but also induces allergies. This study examined glucose- and fibroblast growth factor-2 (FGF-2)-induced cytokine and chemokine expression in adipocytes or adipose tissue-derived stromal cells in vitro to clarify the relationship between adipose tissue and allergies. Glucose and FGF-2 affected cytokine and chemokine secretion, including interleukin-6, monocyte chemotactic protein-1, keratinocyte-derived chemokine, and eotaxin. Allergies will be presumably induced by excess cytokine and chemokine secretion from adipose tissues when overweight children regularly eating high-carbohydrate diets suddenly switch to low-carbohydrate and protein diets.

Free Research Field

細胞生物学