Hybrid protein needle for controlling model animal functions

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560433
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: UENO Takafumi 東京工業大学, 生命理工学研究科, 教授 (70332179)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takashi 東京工業大学, 大学院生命理工学研究科, 准教授 (60612760)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: タンパク質工学 / ケミカルバイオロジー / 一酸化炭素 / フェリチン / バクテリオファージ T４

Outline of Final Research Achievements

This research shows that (1) protein assemblies have advantages as CO releasing molecules, (2) protein needle with optimized surface charge can accumulate on brain of larva. The future challenges, which should be addressed, are (1) ROS and NO assay of eye disc, (2) the ROS imaging, (3) assay for expression of HO and NOS, and (4) inhibitory assay of sGC activation by CO.

Free Research Field

生体関連化学