経頭蓋磁気刺激による気分変調に伴う脳活動の変化のＰＥＴ測定－霊長類モデル研究

2015 Fiscal Year Research-status Report

• Project/Area Number: 26560455
• Research Institution: Tohoku University
• Principal Investigator: 筒井 健一郎 東北大学, 生命科学研究科, 准教授 (90396466)
• Co-Investigator(Kenkyū-buntansha): 林 拓也 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (50372115) ; 尾上 浩隆 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, グループディレクター (80214196)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳・神経

Outline of Annual Research Achievements

機能画像を取得する実験に向けて、経頭蓋磁気刺激の対象とする脳領域や、行動の評価方法を確定させるための予備実験を行った。経頭蓋磁気刺激の対象とする脳領域としては、内側前頭葉の前帯状回脳梁膝周囲部に対する低頻度刺激で、サルの気分状態が著しく低下することが明らかになった。行動の評価方法としては、ケージ内の行動のビデオ画像解析および体に装着した加速度センサーによる自発活動量の解析、改変ブリンクマン課題による意欲の測定などの方法を確立した。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

脳の刺激部位の決定や、行動の評価法を確立のために、当初計画していたよりも大規模に予備実験を行ったために、機能画像の取得には至らなかった。

Strategy for Future Research Activity

十分な予備的データが得られたため、今後は速やかに機能画像を取得する実験を行う。

Causes of Carryover

当初計画していたよりも大規模な予備実験を行ったため、計画していた脳機能画像イメージング実験を行わなかった。

Expenditure Plan for Carryover Budget

脳機能画像イメージング実験を行うために必要な旅費および消耗品費として使用する。

Research Products

• [Journal Article] Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection. (2016)
  • Author(s): Tsutsui KI, Hosokawa T, Yamada M, Iijima T
  • Journal Title: Journal of Neuroscience Volume: 36 Pages: 3038-3048
  • DOI: 10.1523/JNEUROSCI.2063-15.2016.
  • Peer Reviewed
• [Journal Article] Neck collar for restraining head and body movements in rats for behavioral task performance and simultaneous neural activity recording. (2016)
  • Author(s): Tateyama Y, Oyama K, Lo CW, Iijima T, Tsutsui KI
  • Journal Title: Journal of Neruoscience Methods Volume: 263 Pages: 68-74
  • DOI: 10.1016/j.jneumeth.2016.02.005.
  • Peer Reviewed
• [Journal Article] Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum. (2015)
  • Author(s): Oyama K, Tateyama Y, Hernadi I, Tobler PN, Iijima T, Tsutsui KI
  • Journal Title: Journal of Neurophysiology Volume: 114 Pages: 2600-2615
  • DOI: 10.1152/jn.00097.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of G-gene Deletion and Replacement on Rabies Virus Vector Gene Expression. (2015)
  • Author(s): Sato S, Ohara S, Tsutsui KI, Iijima T
  • Journal Title: PLoS One Volume: 10 Pages: e0128020
  • DOI: 10.1371/journal.pone.0128020.
  • Peer Reviewed / Open Access
• [Presentation] Using transcranial magnetic stimulation (TMS) as a tool for primate neuroscience research (2016)
  • Author(s): Tsutsui KI
  • Organizer: 31st International Congress of Psychology (ICP2016)
  • Place of Presentation: 横浜
  • Year and Date: 2016-07-25
• [Presentation] 反復経頭蓋磁気刺激（rTMS）によるサル内側前頭葉の情動・気分調節機能の検証 (2016)
  • Author(s): 筒井健一郎
  • Organizer: 第57回日本心身医学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-06-05
  • Invited
• [Presentation] 経頭蓋時期刺激（TMS）で拓く霊長類研究の新展開 (2015)
  • Author(s): 筒井健一郎
  • Organizer: ナショナルバイオリソース第12回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-12-11
  • Invited
• [Presentation] Cortical and subcortical projections of the entorhinal layer III neurons of the rat. (2015)
  • Author(s): Ohara S., Ito, K., Sota, Y., Tsutsui, K-I., Witter, P. M., Iijima, T.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Rabies virus vector with improved transgene expression level for transsynaptic tracing. (2015)
  • Author(s): Sota, Y., Ohara, S., Sato, S., Ito, K., Tsutsui, K-I., Iijima, T.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] The effect of bimodal value representation on goal directed behavior and reflective choice in behaving macaque. (2015)
  • Author(s): Yasuda M, Nakamura S, Okada KI, Kobayashi Y, Tsutsui KI, Nakamura K.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Comparison of neural representations between rat anterior insular and orbitofrontal cortex in risky decision making. (2015)
  • Author(s): Ishii, H., Kaizu, Y., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Neural responses observed only in a gambling task in the rat anterior insular cortex. (2015)
  • Author(s): Kaizu, Y., Ishii, H., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Cytoarchitectonic information of rat medial prefrontal “delay” neurons revealed by single-neuron electroporation. (2015)
  • Author(s): Oyama, K., Tateyama, Y., Lo, CW., Ohara, S., Karube, F., Fujiyama, F., Iijima, T., Tsutsui, K-I.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Inactivation of rat dorsomedial prefrontal cortex impairs delayed response performance under head fixation (2015)
  • Author(s): Lo C, Tateyama Y, Oyama K, T. Iijima T, Tsutsui KI
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Comparing the impact of online and low-frequency offline rTMS over the unilateral dorsolateral prefrontal cortex on the delayed response task performance. (2015)
  • Author(s): Ogawa K, Nakamura S, Hosokawa T, Iijima T, Tsutsui KI.
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] Neck collar: A novel non-invasive system for restricting head and body movements in rats for behavioral task performance and simultaneous neuron activity recording (2015)
  • Author(s): Tateyama Y, Oyama K, Lo C, Iijima T, Tsutsui KI
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] Ventrolateral prefrontal activity reflects increases in object value induced by larger choice sets. (2015)
  • Author(s): Fujiwara J, Usui N, Eifuku S, Iijima T, Taira M, Tsutsui KI, Tobler P
  • Organizer: Society for Neuroscience Annual Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Morphological identification of rat medial prefrontal neurons showing sustained activity during a delay period of a delayed response task by single-neuron electroporation. (2015)
  • Author(s): Oyama, K., Tateyama, Y., Lo, CW., Ohara, S., Karube, F., Fujiyama, F., Iijima, T., Tsutsui, K-I.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-30
• [Presentation] Afferents and Efferents of the Commissural Projection Neurons in Enthorinal Cortex Layer 3 of the Rat. (2015)
  • Author(s): Ohara, S., Itou, K., Sota, Y., Sato, S., Tsutsui, K-I., Iijima, T.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-30
• [Presentation] Ventrolateral prefrontal activity reflects increases in object value induced by larger choice sets. (2015)
  • Author(s): Fujiwara J, Usui N, Eifuku S, Iijima T, Taira M, Tsutsui KI, Tobler PN.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-29
• [Presentation] An integrated system for the quantitative measure of motivation and emotion in monkeys. (2015)
  • Author(s): Yasuda M, Nakamura S, Okada KI, Kobayashi Y, Tsutsui KI, Nakamura K.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-29
• [Presentation] Risky choice selective neuron in rat anterior insular cortex. (2015)
  • Author(s): Ishii, H., Kaizu, Y., Takahashi, S., Ohara, S., Tobler, N. P., Tsutsui, K-I., Iijima, T.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-29
• [Presentation] Different contributions of monkey frontal, premotor, and parietal corticies in spatial working memory task revealed by on-line rTMS. (2015)
  • Author(s): Tsutsui KI
  • Organizer: International Symposimu on Magnetic Stimulation: Past, Present and Future
  • Place of Presentation: 東京
  • Year and Date: 2015-06-06
  • Int'l Joint Research / Invited