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2016 Fiscal Year Annual Research Report

Neuroimaging of the mood change induced by rTMS: Primate model study

Research Project

Project/Area Number 26560455
Research InstitutionTohoku University

Principal Investigator

筒井 健一郎  東北大学, 生命科学研究科, 教授 (90396466)

Co-Investigator(Kenkyū-buntansha) 林 拓也  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (50372115)
尾上 浩隆  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (80214196)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords脳・神経
Outline of Annual Research Achievements

脳活動の計測対象とするアカゲザル3頭について、内側前頭葉の前帯状回脳梁膝周囲部に対する反復経頭蓋磁気刺激(rTMS)を行い、抑うつ状態を誘発するとともに、血中のコルチゾールレベルもそれに応じて増加することを確認した。その後、コントロール条件である無刺激時の安静時脳活動について計測した。今後は、期間内に実施できなかった、実験条件である内側前頭葉の前帯状回脳梁膝周囲部に対してrTMSを行った後の安静時脳活動の計測を行い、当初の研究目標の速やかな達成を目指す。

  • Research Products

    (16 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results)

  • [Journal Article] Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey2017

    • Author(s)
      Kodama T, Kojima T, Honda Y, Hosokawa T, Tsutsui KI, Watanabe M
    • Journal Title

      Journal of Neuroscience

      Volume: 37 Pages: 2387-2394

    • DOI

      10.1523/JNEUROSCI.2155-16.2017

    • Peer Reviewed
  • [Journal Article] A dynamic code for economic object valuation in prefrontal cortex neurons2016

    • Author(s)
      Tsutsui KI, Grabenhorst F, Kobayashi S, Schultz W
    • Journal Title

      Nature Communications

      Volume: 7 Pages: 12554

    • DOI

      10.1038/ncomms12554

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neck collar for restraining head and body movements in rats for behavioral task performance and simultaneous neural activity recording2016

    • Author(s)
      Tateyama Y, Oyama K, Lo CW, Iijima T, Tsutsui KI
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 263 Pages: 68-74

    • DOI

      10.1016/j.jneumeth.2016.02.005

    • Peer Reviewed
  • [Journal Article] Comparative Overview of Visuospatial Working Memory in Monkeys and Rats2016

    • Author(s)
      Tsutsui KI, Oyama K, Nakamura S, Iijima T
    • Journal Title

      Frontiers of Systems Neuroscience

      Volume: 10 Pages: 99

    • DOI

      10.3389/fnsys.2016.00099

    • Peer Reviewed / Open Access
  • [Journal Article] Similarity in Neuronal Firing Regimes across Mammalian Species2016

    • Author(s)
      Mochizuki Y, OnagaT ... Tsutsui KI ... Shinomoto S
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Pages: 5736-5747

    • DOI

      10.1523/JNEUROSCI.0230-16.2016

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Decision related activities of anterior insular and orbitofrontal cortex in a gambling behavior of rats.2016

    • Author(s)
      Ishii H, Kaizu Y, Takahashi S, Ohara S, Tobler PN, Tsutsui KI,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-14
    • Int'l Joint Research
  • [Presentation] Efferent projections of the calbindinpositive entorhinal neurons in the rat: Connectional differences between the medial and lateral entorhinal cortex.2016

    • Author(s)
      Ohara S, Itou K, Shiraishi M, Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-12
    • Int'l Joint Research
  • [Presentation] rTMSの作用機序解明および臨床利用における刺激条件最適化に向けて2016

    • Author(s)
      筒井健一郎
    • Organizer
      脳科学研究戦略推進プログラム「BMI技術」報告会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-10
    • Invited
  • [Presentation] Using transcranial magnetic stimulation (TMS) as a tool for primate neuroscience research2016

    • Author(s)
      Tsutsui KI
    • Organizer
      31st International Congress of Psychology (ICP2016)
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-25
  • [Presentation] Connectional differences between calbindin positive neurons in the medial and lateral entorhinal cortex of the rat.2016

    • Author(s)
      Ohara S,Itou K,Shiraishi M,Gianatti M,Sota Y,Kabashima S, Onodera M,Tsutsui KI,Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Int'l Joint Research
  • [Presentation] Connectional differences between layer Va and Vb neurons in the lateral entorhinal cortex of the rat.2016

    • Author(s)
      Onodera M, Ohara S,Shiraishi M, Itou K,Tsutsui KI, Witter M,Iijima T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-22
    • Int'l Joint Research
  • [Presentation] Inactivation of rat dorsomedial prefrontal cortex or posterior parietal cortex, but not ventromedial prefrontal cortex, impairs the performance of the visuospatial delayed response task.2016

    • Author(s)
      Oyama K,Lo CW,Tateyama Y,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Int'l Joint Research
  • [Presentation] Neural correlates of abstract thought process in monkey prefrontal cortex.2016

    • Author(s)
      Hosokawa T,Nakamura S,Yamada M,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Int'l Joint Research
  • [Presentation] Reduction of spontaneous physical activity and sociability induced by low-frequency repetitive transcranial stimulation (rTMS) to the lower part of the medial frontal cortex in monkeys.2016

    • Author(s)
      Nakamura S,Ogawa K,Goto Y,Hosokawa T,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Int'l Joint Research
  • [Presentation] Sustained delay activity in mPFC and PPC of head-fixed rats performing delayed pro-/anti-response task.2016

    • Author(s)
      Tateyama Y,Oyama K,Lo CW,Iijima T,Tsutsui KI
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-21
    • Int'l Joint Research
  • [Presentation] 反復経頭蓋磁気刺激(rTMS)によるサル内側前頭葉の情動・気分調節機能の検証2016

    • Author(s)
      筒井健一郎
    • Organizer
      第57回日本心身医学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-06-05
    • Invited

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Published: 2018-01-16  

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