2016 Fiscal Year Final Research Report
Neuroimaging of the mood change induced by rTMS: Primate model study
| Project/Area Number |
26560455
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
NAKAMURA Shinya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 脳・神経 / 抑うつ |
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| Outline of Final Research Achievements |
We applied low-frequency repetitive trans-cranial magnetic stimulation (lf-rTMS) to the ventral part of the medial prefrontal cortex (vmPFC) in rhesus monkeys. After the stimulation, all these monkeys fell into a severe depressive state, which lasted for 1 - 3 days. Such state could be characterized by reduction of within-cage spontaneous activity, reduction of motivation to perform behavioral tasks, and increase in the blood cortisol level. On the other hand, similar stimulation on the posterior part of the anterior cingulate cortex (pACC), or any other cortical regions, did not induce such drastic change in mood. We performed functional MR imaging (fMRI) to measure the resting-state whole brain activity after lf-rTMS to vmPFC and pACC, and sham stimulation to vmPFC. The data is now being analyzed to reveal the difference of the brain activity between the depressive and normal state.
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| Free Research Field |
システム神経科学・生理心理学
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