Generation of sleep disorder model using genome engineering tool

2015 Fiscal Year Final Research Report

• Project/Area Number: 26560458
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: Ueno Taro 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (30648267)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: CRISPR/Cas9 / 精神疾患 / 睡眠障害

Outline of Final Research Achievements

In this study I tried to create disease model using genome engineering tool and clinical database. I focused on sleep disorder and used drosophila melanogaster as model organism. Fly mutants with candidate genes for Kleine-Levin syndrome or autism spectrum disorder are created using CRISPR/Cas9 system.

Free Research Field

睡眠医学