Development of on-chip mass spectroscopy

2017 Fiscal Year Final Research Report

• Project/Area Number: 26600059
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nano/Microsystems
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: Takamura Yuzuru 北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (20290877)
• Co-Investigator(Kenkyū-buntansha): 浮田 芳昭 山梨大学, 大学院総合研究部, 助教 (40578100)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 質量分析 / タンパク質のイオン化 / MALDI / 熱パルスイオン化 / マトリックスフリー / 糖のイオン化 / イオン化メカニズム / マイクロ流体デバイス

Outline of Final Research Achievements

This research tried to miniaturize mass spectroscopy on a chip. Especially, pulse heating ionization and dissociation method (PHDI) was developed. In this method, samples were ionized and dissociated by a heat pulse generated by micro heater on chip. PHDI was found to be a novel ionization method with extremely excellent properties that PHDI not always requires matrix assist for ionization and can ionize wide range of materials from inorganic to macromolecule, including proteins, hydrocarbons and sugars, with very high efficiency and qualities of soft-ionization.

Free Research Field

分析化学、マイクロ流体デバイス