2015 Fiscal Year Final Research Report
Development of sharp tip-separable micro device for trans-dermal drug delivery systems
| Project/Area Number |
26600060
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Hiroshima City University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | MEMS / マイクロニードル |
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| Outline of Final Research Achievements |
MEMS technology was applied to produce microneedles for trans-dermal drug delivery system. A Si pyramidal shaped microneedle was firstly fabricated by photolithography and anisotropic wet etching. A sharp tip separable microneedle device was developed by applying the Si microneedle working as a master. A polydimethylsiloxane (PDMS) mold was produced by the Si microneedle. Firstly, the supporting base was fabricated by the PDMS mold, then polymer solution was filled into the PDMS mold. The sharp tip separable microneedle device was produced by inserting the supporting base into the mold with the specific amount of the gap. The insertion and separation of the tip-separable microneedle device was challenged. A PDMS material was applied as an artificial skin, because it has the similar value of Young's modulus with that of the skin. The fabricated tip-separable microneedle device was fully inserted into the artificial skin, and the tip was successfully separated and placed into the skin.
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| Free Research Field |
ナノマイクロ科学
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