2016 Fiscal Year Final Research Report
Development of 3-dimensional-structure sensors with molecular-level resolution and their application to solid/liquid interface analysis on biocells.
| Project/Area Number |
26600065
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nano/Microsystems
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 表面・界面 / プラズモニクス / 表面増強ラマン散乱 / 細胞表面 / ナノ・マイクロファブリケーション / 固液界面 |
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| Outline of Final Research Achievements |
A novel measurement tool, which is capable to analyze chemical structures of ultra-thin films or interfaces, has been developed, based on surface enhanced Raman scattering with newly developed “plasmon sensors,” which enhances local intensity of the Raman signals. Various types of the plasmon sensors have been developed, and as a result, ultra-thin organic films, i.e. self-assembled monolayers, lipid bilayers, cell membranes, were successfully analyzed. Particularly, inner chemical structure of the films was measured with a depth resolution of 0.1nm. Developed methodology is expected to apply wide areas such as diagnostics of various types of cells (e.g., cancer cells) as well as fundamental researches for biomedical field.
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| Free Research Field |
機能表面化学
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