Discovery of New Catalytic System for Efficient Transformation of C–H Bonds

2016 Fiscal Year Final Research Report

• Project/Area Number: 26620083
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: National Institute of Advanced Industrial Science and Technology (2016); Kyoto University (2014-2015)
• Principal Investigator: Yada Akira 国立研究開発法人産業技術総合研究所, 触媒化学融合研究センター, 研究員 (70619965)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 炭素-水素結合 / 不活性結合活性化 / パラジウム

Outline of Final Research Achievements

In order to improve the practicality and efficiency of the transition-metal catalyzed C-H bond functionalization reaction, new catalytic reactions that consist of the introduction of an activating group into an organic molecule, the bond formation reaction, and recycle of the activating group, were investigated. As the result, unexpected effect of salicylaldehyde which act as the multipurpose directing group that is easily available, installable, removable, and recoverable, for palladium-catalyzed arylation reaction of primary amines was developed. In addition, a palladium-catalyzed intramolecular insertion of alkenes into carbonyl C-N bonds of β-lactams affording nitrogen-containing fused bicyclic compounds was discovered.

Free Research Field

有機合成化学