Nerve cell growth control by cell adhesion peptide nanofibers that regularly arranged on a polymer interface

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620102
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Tanaka Naoki 京都工芸繊維大学, 分子化学系, 教授 (60243127)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 熱ショック蛋白質 / ペプチド / 細胞培養 / ポリスチレン / 神経細胞

Outline of Final Research Achievements

A peptide sequence corresponding to the substrate binding site heat shock protein α-crystallin (αAC (71-88)) form a nano fiber that has the ability to adsorb the protein by heat treatment. In this study, new peptide nano fiber with an affinity for hydrophilic polystyrene and cell surface by introducing a lysine and arginine for the amino acid sequence of αAC (71-88). It was designed to cell adhesion to bond the cell and the substrate . By mixing a peptide incorporating the peptide in sequence IKVAV, peptide nanofibers could be promote cell proliferation of PC12, a neuronal cell model.

Free Research Field

高分子化学