Prepration and Function of Dynamic Sulfated Glycopolymers

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620106
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: Kyushu University
• Principal Investigator: Miura Yoshiko 九州大学, 工学(系)研究科(研究院), 教授 (00335069)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 糖鎖高分子 / 生体関連高分子 / 分子認識

Outline of Final Research Achievements

Various glycopolymers were prepared with different sugar ratio, density and physical properties. The glycopolymers were prepared as linear polymers, nanogels, and polymer monolith. Not only were the density of sugar, but also physical properties of the glycopolymers important for protein recognition. Target proteins depended on the sugar structure, and sulfated glucosamine bound to the enzyme and growth factors.
The polymer monolith was also prepared with the same method with condensed condition under the mixture of DMSO and alcohol. The glycopolymers with various saccharides were prepred via living radical polymerization and click chemistry.

Free Research Field

高分子化学