Development of bioelectrode capable ofsition and disappearance decompo

2016 Fiscal Year Final Research Report

• Project/Area Number: 26620126
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: National Rehabilitation Center for Persons with Disabilities
• Principal Investigator: Toyama Shigeru 国立障害者リハビリテーションセンター(研究所), 研究所 障害工学研究部, 研究室長 (50360681)
• Co-Investigator(Renkei-kenkyūsha): KANSAKU Kenji 国立障害者リハビリテーションセンター, 研究所・脳機能系障害研究部, 研究室長 (60399318) ; TANAKA Yasuhiro 国立障害者リハビリテーションセンター, 研究所・障害工学研究部, 流動研究員 (80568113)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生体電極 / セルロース / セルラーゼ

Outline of Final Research Achievements

We aimed to develop bioelectrodes that can be disassembled at arbitrary timing. We focused on cellulose to realize this. Cellulose has no decomposing enzymes in the human body and can exist stably. Also it has biocompatibility as it is used as a dialysis membrane. Moreover, it is decomposed by cellulase derived from microorganisms. Therefore, we have developed a cellulose-based electrode which is easily decomposed by injecting cellulase. First, we developed a method to make cellulose tubes of various diameters. Then an electrode composed of a plurality of cellulose tubes (imparting conductivity by injecting an electrolyte into the inside) was prepared. It was confirmed that this electrode was decomposed by implanting it into the model biogel and injecting cellulase halfway.

Free Research Field

電気化学