Liposomal crosslinker for cell sorting and functional matrix

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620136
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kyushu University
• Principal Investigator: Mori Takeshi 九州大学, 工学(系)研究科(研究院), 准教授 (70335785)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: セルソーティング / マトリックス

Outline of Final Research Achievements

I studied the usage of antibody-modified liposome for cell sorting and matrix. Epithelia form aggregate not only by liposome but also by endogenous adhesion molecules. On the other hand, I found that floating cell (K562) can not be crosslinked by this method. I attributed this to the dissociation of antibody during cell aggregation process. Thus, I developed new lipid molecule which stable anchor on liposomal membrane. I found that the synthesized lipid was homogenously dispersed in the membrane.

Free Research Field

バイオマテリアル