Design of beta-sheet inhibitors based on peptide metal complex arrays

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620139
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: National Institute for Materials Science
• Principal Investigator: TASHIRO KENTARO 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (40332598)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 多核金属錯体 / ペプチド / 自己集合 / アミロイド / アニオン依存性

Outline of Final Research Achievements

Design of water-soluble peptide metal complex arrays and studies on their self-assembling behaviors revealed their unique dependency on the co-existent anions, which is clearly different from the general tendency of peptides and proteins, known as “Hofmeister series” A water-soluble peptide metal complex array was found to inhibit the amyloid fibril formation of an amyloidogenic peptide and digest its preformed amylid fibers.

Free Research Field

金属錯体化学