A New development of Controlling Stem Cells by Using Honeycomb Scaffolds

2015 Fiscal Year Final Research Report

• Project/Area Number: 26620170
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer/Textile materials
• Research Institution: Tohoku University
• Principal Investigator: YABU HIROSHI 東北大学, 多元物質科学研究所, 准教授 (40396255)
• Co-Investigator(Kenkyū-buntansha): KATO Ryuji 名古屋大学, 創薬科学研究科, 准教授 (50377884)
• Co-Investigator(Renkei-kenkyūsha): NAKAJIMA Ken 東京工業大学, 理工学研究科, 教授 (90301770)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 自己組織化 / ハニカム状多孔質膜 / 幹細胞 / 分化 / 接着

Outline of Final Research Achievements

Honeycomb patterned scaffolds have been fabricated by casting solutions of polybutadiene (PB) and polystyrene (PS) containing amphiphiles under humid conditions. Flat films of these materials were also prepared as reference films. By irradiation of UV light, PB honeycomb and flat scaffolds were cross linked. By using an atomic microscope, surface modulus of each sample has been measured. The measurement revealed that surface modulus increased by UV irradiation. Human mesenchymal stem cells were cultured on these scaffolds and we found that adhesion and differentiation of human mesenchymal stem cells were modulated by changing scaffold parameters including surface modulus and pore sizes. These results will open a path to a new development on controlling behavior of stem cells.

Free Research Field

高分子化学