Basic Reseach on External Stimulation Responsive Drug Delivery Systems Using AC Electroosmosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26630035
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Design engineering/Machine functional elements/Tribology
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Yoshida Kazuhiro 東京工業大学, 科学技術創成研究院, 教授 (00220632)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 先端機能デバイス / マイクロ・ナノデバイス / 交流電気浸透 / ドラッグデリバリ―システム / 医療・福祉 / MEMS / 電鋳 / マイクロポンプ

Outline of Final Research Achievements

As a principal component of small-sized advanced external stimulation responsive drug delivery systems, a novel ac electroosmotic micropump using a plate-cylinder electrode array was proposed and developed. First, the micropump using a pair of plate and cylinder electrodes was proposed and characterized by simulation based on finite element method. Second, the micropump using a plate-cylinder electrode array was proposed, fabricated using micro electroforming, and characterized experimentally. Third, higher output power due to miniaturization of cylinder electrodes was experimentally confirmed. Finally, higher output power due to electric field modification by adding electrodes was investigated by simulation and experiments. A part of fundamental technologies to realize small-sized advanced external stimulation responsive drug delivery systems was established.

Free Research Field

機械工学