Fusion of the high shear field thrombus detection and the red blood cell membrane rupture simulation in the artificial organ

2015 Fiscal Year Final Research Report

• Project/Area Number: 26630046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Chiba University
• Principal Investigator: TAKEI MASAHIRO 千葉大学, 工学(系)研究科(研究院), 教授 (90277385)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Masanori 埼玉大学, 理工学研究科, 准教授 (20448046) ; MARUYAMA Osamu 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 研究グループ長 (30358064)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 血栓 / 誘電緩和法 / 緩和周波数 / ACT / シミュレーション / 赤血球凝集

Outline of Final Research Achievements

Experiments of thrombus formation and thrombus measurement using relaxation frequency have been carried out at shear force field of solid liquid two phase flow of red blood cell and plasma. The relaxation frequency is increased as the time elapses, and is decreased after reaching the peak point. At the peak point, the value of ACT fell below the reference value, and the amount of fibrinogen is sharply decreased. It becomes clear that the peak point of the relaxation frequency matches the start of the RBCs aggregation. Calculation results of the simulation modeling of the thrombus formation process indicated that RBCs aggregation affects the relaxation frequency similarly to the experimental results

Free Research Field

固液二相流