Bottom-up design of bio-molecular circuits based on structure-robust analysis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26630195
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Control engineering/System engineering
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Imura Jun-ichi 東京工業大学, 情報理工学(系)研究科, 教授 (50252474)
• Co-Investigator(Kenkyū-buntansha): INOUE Masaki 慶應義塾大学, 理工学部, 助教 (80725680)
• Co-Investigator(Renkei-kenkyūsha): AIHARA Kazuyuki 東京大学, 生産技術研究所, 教授 (40167218) ; SUZUKI Masayasu 宇都宮大学, 工学部, 助教 (10456692)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 生体分子回路 / 分岐解析 / 合成生物学 / ロバスト性解析

Outline of Final Research Achievements

In this research project, we aim to propose a new design strategy of a large-scale bio-molecular circuit which has desired functions. To this end, the following two problems are addressed. 1) For interconnected nonlinear dynamical systems, a computational method of evaluating the robustness of the structural property was proposed. The method is applied to design problem of a bio-molecular switch that models the decision maker of cell fate. 2) We found a special class of dynamical systems that reinforce the robustness via their interconnection. The class is generalized to model a bio-molecular system that expresses the differentiation of a stem cell. It is mathematically shown that the robustness of a function derived from the differentiation is reinforced via bottom-up construction. The robustness reinforcement is illustrated in numerical experiments as well.

Free Research Field

制御工学