Development of Calcium Phosphate-based Hybrids indicating Environmental Responsiveness

2015 Fiscal Year Final Research Report

• Project/Area Number: 26630310
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Inorganic materials/Physical properties
• Research Institution: Nagoya University
• Principal Investigator: OHTSUKI Chikara 名古屋大学, 工学(系)研究科(研究院), 教授 (00243048)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ハイブリッド材料 / セラミックス / 生体材料 / ヒドロキシアパタイト / 擬似体液

Outline of Final Research Achievements

In this study, fundamental conditions for modification of calcium phosphate-based materials were investigated to develop novel bone substitutes responsible to existence of enzyme in surrounding environment. Alkaline phosphatase (ALP) was used as an enzyme, which enhances hydrolysis of phosphoric esters. Formation of hydroxyapatite (HAp) from calcium salts of phosphoric esters was examined in a simulated body fluid (SBF) containing ALP. The dissolution of calcium salts of phosphoric esters and their hydrolysis by ALP allow increase in concentration of calcium ions and phosphate ions, resulting in formation of HAp. Formation rate of HAp from calcium salts of phosphoric esters with different alkyl chain length mainly depends on the hydrolysis rate of the corresponding phosphoric esters by ALP. Alpha-Tricalcium phosphate (TCP) ceramic was successfully modified with buthylphosphate to result in coating of calcium salts of butylphosphoric acid on bioabsorbable body.

Free Research Field

工学