Development of innervated skeletal muscle on chip

2015 Fiscal Year Final Research Report

• Project/Area Number: 26630429
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biofunction/Bioprocess
• Research Institution: Nagoya University
• Principal Investigator: Shimizu Kazunori 名古屋大学, 工学(系)研究科(研究院), 准教授 (70402500)
• Co-Investigator(Kenkyū-buntansha): MORI Hideki 大阪府立大学, 大学院理学研究科, 准教授 (30450894)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: バイオマイクロデバイス / 磁性ナノ粒子 / 骨格筋細胞 / 神経細胞 / 細胞アッセイ

Outline of Final Research Achievements

The objective of this study is to develop innervated skeletal muscle on chip. We developed several elemental technologies. We succeeded to pattern the attachment of neurons and skeletal muscle myotubes by a cell patterning method using magnetite nanoparticles and magnetic force, or micro fluidic devices. Also, we succeeded to measure the contraction force of cultured myotubes noninvasively by using the developed microdevice. Hereafter, we plan to integrate these elemental technologies.

Free Research Field

生物化学工学