2015 Fiscal Year Final Research Report
Analysis of changes in the systemic immune response connected to brain function by applying new technology for artificial manipulation of specific-neural brain network
| Project/Area Number |
26640015
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Hoshi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 脳末梢連関 / 視床下部 / オピオイド神経 / 抗腫瘍免疫 / DREADD / 細胞性免疫 |
|---|
| Outline of Final Research Achievements |
In this research, we investigated the changes in the anti-tumor immune response by an activation of the hypothalamic POMC neurons oriented from the arcuate nucleus (ARC), using optogenetics and designer receptors exclusively activated by designer drugs (DREADD) technology, in order to elucidate how the activation of the central nervous system could affect the innate immune system in the development and progression of cancer. As a result, we found that the activation of the hypothalamic POMC neurons in the ARC may suppress the peripheral tumor growth associated with enhancing cell-mediated immunity via activation of the μ-opioid receptor located in paraventricular nucleus of the hypothalamus (PVN).
|
| Free Research Field |
神経科学
|
