2016 Fiscal Year Final Research Report
Discrimination of sensory signaling in pheromone and temperature-sensing neuron
| Project/Area Number |
26640018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Konan University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | C. elegans / 区別識別 / 線虫 / 3量体Gタンパク質 / カルシウムイメージング |
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| Outline of Final Research Achievements |
How multiple neural signaling is discriminate and crosstalk in the neuron is important question. Here we established experimental system for analyzing their processing of multiple neural signaling. We found that a sensoryneuron known as pheromone and light sensing-neuron acts as a thermosensoryneuron. In this multi stimuli common sensoryneuron, trimeric G protein, our culcium imaging revealed that guanylyl cyclase and phosphodiesterase regulates pheromone, light and temperature signaling. However, we found that GPA-1 encoding G protein alpha subunit and PDE-3 encoding phosphodiesterase control temperature signaling specifically. These results suggest that commonalities and differences in the molecular components concerned with pheromone, light and temperature signaling in a single sensory neuron.
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| Free Research Field |
分子神経遺伝学
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